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To delineate the neural mechanism behind these observations, a complimentary anatomical study in rats showed RGC axons interacting with hypothalamic neurons that project directly to the brainstem (superior salivatory nucleus, SSN) and spinal cord (intermediolateral nucleus, IML) nuclei involved in parasympathetic and sympathetic regulation, respectively
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This study, the CARES trial, looked at 5000 patients, all of whom had some cardiovascular disease history, either heart attack, stroke, min-stroke or need for urgent heart surgery for coronary disease
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