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Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibody production, immune complex deposition, tissue inflammation and damage of multiple organs ( - CD8 - ) T cells, are involved through distinct mechanisms in the development of organ inflammation in SLE ( Recent studies have shown that the differentiation and function of each T cell subset is controlled by intracellular metabolic processes ( Amino Acid Transporters Amino acid transporters are important in transporting amino acids from the environment into the cell ( Slc7a5 -/- CD4 + T cells cannot respond to antigen, undergo clonal expansion or effector cell differentiation

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EGT, in comparison, influences mitophagy primarily through maintenance of mitochondrial redox balance and preservation of iron–sulfur cluster stability rather than through direct stimulation of canonical mitophagy pathways