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DNA hypermethylation caused by loss of TET activity increases nucleosome occupancy, and subsequently, loss of CTCF binding and a block in the downstream recruitment of the cohesin complex, reducing the formation of CTCF/cohesion-mediated chromatin loops thereby downregulating the expression of neighboring genes (Wiehle et al., 2019

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B12 Guidelines flowchart B12 Guidelines flowchart B12 Guidelines Version 1.0 Approved Details Versions Document Type Basic Document Extension png Size 232 KB Modified 17/03/26, 15:10 by Polly Fulchini Created 17/03/26, 15:10 by Polly Fulchini Expiration Date Never Expire Review Date Never Review Location Tags haematology flowchart document Categories Harrogate and District NHS Foundation Trust Haematology Version 1.0 By Polly Fulchini, on 17/03/26, 15:10 No Change Log B12 Guidelines flowchart (Version 1.0)