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Clinical Update 4/26/2022 B-12 for Nighttime Leg Cramps Raising lower blood levels of vitamin B-12 may help with nighttime leg cramps according to some reports

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These heterodimers interact with Raptor, a member of the mTORC1 complex, which in turn localizes the complex to the surface of late endosomes and lysosomes where it is activated by RHEB‐GTP (Martina & Puertollano, 2013