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GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review - PMC

Managing Nausea and Side Effects Through Strategic Timing Nausea is the most commonly reported side effect in the first 4–8 weeks of tirzepatide therapy, and injection timing can influence its severity

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and (4) a reduced leg withdrawal reflex, as evaluated by the hot-plate test 1 week after paraquat administration [98]