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Hydrogen bonds that form between Arg250 and Asp400 appear to ‘stretch’ the alpha helix containing Asp400, causing Tyr399 on the N-terminal end of the alpha helix to insert further into the active site where the substrate binds (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Li J, Peng T, Wang L, Long P, Quan R, Tan H, et al