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The rate of loss accelerates during the dose escalation phase and typically peaks around weeks 16-32 when you reach higher maintenance doses

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In a meta-analysis review of 19 studies on neuropathic pain (10 studies for intravenous lidocaine and 9 for mexiletine), [46] it was noted that intravenous lidocaine and mexiletine were superior to placebo and equal to morphine, gabapentin, amitriptyline, and amantadine