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The network for these included studies for evaluating weight loss, HbA1c, weight percent, adverse events, and treatment discontinuation rates was shown in Figure 2A–E and Supplement 8.1 to 8.5, respectively, and the characteristics of studies and patients' baseline features are presented in Supplements 2 and 3

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Unlike oral semaglutide (Rybelsus), which must be taken on an empty stomach with no more than 4 ounces of water and requires waiting 30 minutes before eating, drinking, or taking other medications, orforglipron can be taken at any time of day, with or without food, and with any beverage