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[accessed 9 th February 2026] Effectiveness of Dulaglutide in the Real World and in Special Populations of Type 2 Diabetic Patients (2020) NIH [accessed 9 th February 2026] Lilly’s SURMONT-2 results published in The Lancet show tirzepatide achieve a mean weight reduction of 15.7% at the highest dose (15mg) in adults with obesity or overweight and type 2 diabetes (2023) Eli Lilly [accessed 9 th February 2026] Tirzepatide for managing overweight and obesity (2024) NICE [accessed 9 th February 2026] Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial (2022) Nature Medicine [accessed 9 th February 2026] Once-Weekly Semaglutide in Adults with Overweight or Obesity, The New England Journal of Medicine [accessed 9 th February 2026] Medically reviewed by reviewed by Sunny Dhain (MPharm, PGDip, IP, MRCPharm) GPhC Number: 2073665 Last reviewed: 18th August 2026 Meet our medical professionals medical professionals Sunny Dhain Clinical Director Kamaldeep Kaur Pharmacist Prescriber Aaliyah Nelson Nutritional Coaching BSc (Hons) Nutrition: 47988 Standards first always always