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Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression

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Fibroblast production of type I and III collagen, glycosaminoglycans and decorin has been measured in culture, alongside changes in extracellular matrix architecture