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To determine intracellular metabolite values from subcutaneous tumors, flash frozen tissues (100 mg per sample) were homogenized using a liquid nitrogen–cooled mortar and pestle

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Neuroimaging studies of irradiated and nonirradiated ALL survivors demonstrate a variety of CNS abnormalities, including leukoencephalopathy, cerebral lacunes, cerebral atrophy, and dystrophic calcifications (mineralizing microangiopathy).[53,59,108,109] Among these, abnormalities of cerebral white matter integrity and volume have been correlated with neurocognitive outcomes