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Slowness of movement and other neurological features typically observed in Parkinson’s disease such as hypomimia, shuffling gait, impaired fine finger movements and foot tapping are further typical features

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Most importantly, unlike the irreversible glucuronidation reaction, sulfoconjugation is reversible by sulfatases [35], among which is arylsulfatase A (ARSA), which converts the biologically inactive DA-S to a nonconjugated, active DA