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Consequently, levodopa can provide symptomatic relief throughout most of the day with the right dosing regimens, though this may lead to increasing regimen complexity in advanced disease
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The major biological factors that drive the observed sex differences in AD include differences in age-related sex hormone reduction, the incidence of genetic risks (ApoE, etc.), the impact from risks of other diseases (diabetes, depression, cardiovascular disease), and the age-related declines in brain volume and brain glucose metabolism (247, 252, 258, 263)