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La B12 libre se lie à certaines protéines de transport présentes dans le plasma : les haptocorrines, aussi appelées cobalophilines ou transcobalamines, parmi lesquelles on distingue la transcobalamine I, II et III

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Additionally, impairments in GABAergic circuits, especially within the primary motor cortex, have been noted in these patients, connecting these disruptions to both cognitive and physical fatigue [50]

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