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Accordingly, we found that IGF-1 null mice that exclusively express hepatic IGF-1 transgene (KO-HIT mice) [50] show increased levels of lipid peroxidation products in serum and increased mortality rate at 18 months of age in both sexes, suggesting that elevations in serum IGF-1 are harmful

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Barnaby D.P., Becker L.B., Chelico J.D., et al