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From the several sites that can generate superoxide in the mitochondrial matrix, only the superoxide produced at complex III appears to be released both into the matrix and the IMS (Quinlan et al., 2013)

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An emerging body of evidence suggests possible antidepressant effects resulting from probiotic supplementation, which can normalize depression-associated physiological outputs, such as corticosterone, noradrenaline, BDNF, and immune function