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Extensive evidence from randomized clinical trials and thorough meta-analyses supports the efficacy of long-term NAC administration in decreasing the risk of AECOPD [88,94,96,97] and establishes a dose-related protective effect [96,97]

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Some pathological gut diseases associated with impaired intestinal barrier permeability may trigger EGCs dysfunction and transition to a pro-inflammatory phenotype (Benvenuti et al., 2020)