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Oral administration to diet-induced-obese mice for ~10 days reduces fat mass without altering food intake, decreases adipocyte size, restores insulin sensitivity, and increases adipose NAD⁺ and SAM levels [2]

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9 However, qualitative results (responses to free-text items in this study) show that SMVI was common before This study relies on self-reported diagnosis and recruitment from online support groups that evidence suggests has some limitations