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The SURMOUNT-1 trial demonstrated average weight loss of 20.9% of body weight at the highest dose over 72 weeks—surpassing semaglutide's results

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Mechanism Selective NNMT (nicotinamide N-methyltransferase) inhibition, proposed to preserve intracellular NAD+ and SAM and reduce fat-cell lipogenesis — demonstrated in cells and mice, never in humans