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Excessive depletion of oxidants may result in the induction of reductive stress, characterized by declined physiological functions, such as suppressed mitochondrial function, cell proliferation, the occurrence of cardiomyopathies, and other pathologies (Rajasekaran et al
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That means high-dose oral B12 (around 1000µg daily) can raise levels even in some people with absorption problems, and studies have shown high-dose oral treatment can be an effective alternative to injections in selected patients
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