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Beginning with THF, the serine/glycine hydroxymethyltransferases encoded by the SHMT1 and SHMT2 genes generate 5,10-methylene-THF ( N 5 , N 10 -methylene-THF)

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It has been proposed that the antioxidant actions of bilirubin are a result of an amplification cycle whereby bilirubin acting as an antioxidant, is itself oxidized back to biliverdin and then recycled back to bilirubin via biliverdin reductase (41)