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In addition, amino acids seem to regulate mTORC1 through a TSC-Rheb-independent pathway, as growth factors do not activate mTORC1 efficiently in amino acid-deprived conditions and total amino acid deprivation can suppress mTORC1 signaling even in Tsc2−/− cells where mTORC1 is hyperactivated (Smith et al., 2005)
In cells glutathione either exists as reduced (GSH) and oxidized (GSSG)