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Instead, AOD 9604 is used to study downstream metabolic signaling, particularly adipose tissue lipolysis, allowing researchers to isolate lipid metabolism pathways without engaging the broader endocrine GH–IGF-1 axis

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For instance, a recent study revealed that microbial metabolic disorders leading to Th17/Treg imbalance can trigger hepatocyte ferroptosis, potentially explaining the involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease [81]