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[3] In the phase 3a REDEFINE 2 trial in adults with overweight or obesity and type 2 diabetes, once-weekly cagrilintide–semaglutide (2.4 mg of each) produced an estimated mean body-weight change of −13.7% versus −3.4% for placebo over 68 weeks

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Rotating injection sites consistently and allowing the solution to reach room temperature before injecting minimizes these reactions