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Its name is short for “mitochondrial ORF of the 12S rRNA type-C,” which refers to the peptide’s origin, as it’s derived from lengths of DNA called short open reading frames (ORFs) found in the 12S rRNA region of mitochondrial DNA.1 2 Seeing as MOTS-c’s mitochondrial origin is pivotal to understanding what the peptide can do for you and how it works, we think now’s a good time for a mitochondria primer
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