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At the transcriptional and protein levels, OY also suppressed the expression of several hub genes linked to ferroptosis–inflammation synergy, including NOS2 , HIF1A , IDO1 , DUOX2 , and TIMP1 ( 3.2.4.2 Colorectal cancer (CRC) Bioinformatics screening across multiple datasets identified five key ferroptosis-related genes, including ELAVL1 , GPX2 , EPAS1 , SLC7A5 , and HMGB1 , with significant dysregulation in CRC tissues
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