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Cadmium may accentuate inflammatory processes, which may in turn disrupt the HPA axis and trigger symptoms of ME/CFS (161, 162)

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Protein kinases such as protein kinase A have been shown to phosphorylate hPXR, mostly reducing its activity by retaining it in the cytoplasm and preventing it from binding to nuclear DNA, thus suppressing the transcription of downstream genes [11, 12]