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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig
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[DOI] [PubMed] [Google Scholar] 34.Fréry N, Huel G, Leroy M, Moreau T, Savard R, Blot P, Lellouch J
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