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Metabolic stability studies indicated valproate’s metabolism is not primarily eliminated through CYP450, suggesting that the in vivo interaction likely results from inhibition of β-oxidation or glucuronidation
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These results suggest that NtGSTU10 overexpression is associated with transcriptional changes in pathways related to signal transduction, carbon metabolism, and substance biosynthesis and transport, which may contribute to the altered nicotine accumulation observed in tobacco leaves
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