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Moreover recent analysis of the circadian transcriptome shows that liver possesses the highest number of rhythmic genes, while brain has the lowest ( FIGURE 6 Another important finding of our study is that the diurnal fluctuations in GSH levels were not followed by similar changes in the products of its degradation (Cys-Gly) and oxidation (GSSG)

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These pathways include sulfation, glucoronidation, glutathione conjugation, acetylation, amino acid conjugation and methylation