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FDX1 is predominantly downregulated in various types of cancer tissues, particularly in solid tumors, including clear cell renal cell carcinoma (ccRCC), breast invasive carcinoma, colon adenocarcinoma, lung adenocarcinoma, thyroid carcinoma, and HCC

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This depletion creates a vicious cycle: the body lacks the nutritional tools necessary to quench the inflammatory fire, allowing the oxidative stress to persist and cause further cellular damage