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To identify the pro-myelinating drug, we evaluated five TCM monomers, including gastrodin, paeoniflorin, puerarin, salidroside and scutellarin (Fig
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Specifically, VEGF-A binding to VEGFR2 or shear stress activates the PI3K/AKT pathway, stimulating eNOS to produce vasodilators such as NO and prostacyclin (PGI2), highlighting the critical role of VEGF signaling in vascular tone regulation
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