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Zhang and collaborators showed different mechanisms to explain the differential sorting of DOR (Zhang et al., 2008): when the receptor is phosphorylated by GRK2 and internalized via arrestins it can recycle whereas in a non-phosphorylated form DOR undergoes an arrestin-independent sequestration which is followed by a degradation

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The arginate form is of particular interest in gastrointestinal research where oral administration routes are being studied