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In the canonical pathway, the Wnt ligands (Wnt1, Wnt2, Wnt3, Wnt3a, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt10b, or Wnt16) bind to corresponding Frizzled receptors (10 kinds found in human and mice) and low-density lipoprotein receptor-related proteins 5/6 (LRP5/6) co-receptors on the cell surface, to initiate intracellular signal transduction through nuclear translocation of β-catenin 14