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In contrast to iron removal from transferrin, lactoferrin, ferritin and hemosiderin, no iron removal has been shown by chelators or chelating drugs from other proteins of iron metabolism, which include hemoglobin, myoglobin, cyclooxygenase, lipoxygenase and ribonucleotide reductase [152]

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NNMT is expressed primarily in adipose tissue and liver, meaning systemic bioavailability after subcutaneous injection matters more than peak plasma concentration