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Indeed, the structural and functional abnormalities of lysosomes are critical for the pathogenesis and development of various diseases, including tumors 14,15,16 , neurodegenerative diseases 17,18,19 , inflammatory diseases 20,21,22 , and cardiovascular diseases 23,24,25 , making LQC a novel but pivotal target for treatments

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GSH and GSSG recycling occurs via GPx and glutathione reductase, a process integral to regulation of ferroptosis, emerging as a contributor to neuronal death after TBI [45] and hemorrhagic stroke in mice [46]