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The involvement of these distant organs in IR injury significantly complicates clinical outcomes, increasing the risk of multi-organ failure and underscoring the need for targeted therapeutic interventions
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While vimentin does not directly regulate transcription of HLA class II genes such as DRB1 and DQA1, it plays a supportive role in the antigen-presenting function of macrophages and dendritic cells (Yu et al., 2018
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