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A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule (Hammes et al., 2011), and possibly invoke effects of the adjacent subunit of the dimeric enzyme for a deeper insight into structural requirements for the isomerization mechanism

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Neither of these epitopes are involved in the TSH binding pocket [50], and thus neutral TSHR-mAbs fail to block TSH binding to the receptor