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The gastrointestinal tolerability profile can be significantly improved through slow, gradual dose titration over several weeks, starting with low doses and incrementally increasing, which allows the body to adapt to gastric slowing effects

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Water-based 2K coatings with improved performance are emerging, such as Dow's MAINCOTE AEH acrylic-epoxy hybrid technology and Hexion's method for producing resins for 2K-PU water-based topcoats