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Disclosure of interest: Malini V Sagar: funding from Innovation Fund Denmark and Herlev & Gentofte Hospital's internal research fund, Christian H Krag: funding from Innovation Fund Denmark, Karen L Gandrup: nothing to disclose, Mikael P Boesen: nothing to disclose, Christina R Kruuse: local PI for trials by Bayer A/S and Bristol Myers Squibb Ab, grant recipient of the Novo Nordisk Foundation, Lundbeck Foundation, and Trygfonden