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Infarct size is reduced to 6.2% compared to 18.1% (PEG-PUE-SLN), 28.3% (PUE-SLN), and 36.0% (free puerarin), representing an 83% reduction versus free drug and a 66% reduction versus non-PEGylated nanoparticles, demonstrating the superior cardioprotective effect of dual-targeting ( In vivo , RGD-S/P-LPNs demonstrate prolonged circulation, increased AUC, enhanced myocardial drug delivery, and significantly reduced infarct size, outperforming single-drug and non-targeted formulations through confirmed synergistic cardioprotective efficacy in acute myocardial ischemia
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