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The principal serious adverse reactions are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain and/or pleural effusion, (2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births and (4) Arterial thromboembolism
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One synthetic peptide corresponding to the loop region of hLfcin (HLT1, 16 residues) and another peptide corresponding to the charged portion (HLT2, 11 residues) were prepared and assayed against pathogenic strains of Escherichia coli serotype O111, a species in which apo-Lf alone does not have an effect
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