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High extracellular ADO levels, by ligation of low affinity ADORA2B, can influence the antigen-presenting activity of DCs (79, 80) and activate normal infiltrating cells that block the anti-tumor immune response (such as Tregs, MDSCs, and TAMs) (81), leading to peripheral tolerance (Figure 2)

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In regenerative orthopedics, it is typically used for the treatment of muscle strains, tears, ligament and tendon tears, minor arthritis, and joint instability