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Irinotecan (CPT-11 or ( S )-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3′,4′:6,7)-indolizino(1,2-b) quinolin-9-yl-(1,4′-bipiperidine)-1′-carboxylate) is a topoisomerase II inhibitor that is the first-line treatment for metastatic colorectal cancer