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Conclusions It is established that malfunctional ATP7B is the trigger of liver injury

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It plays a critical role in: Blood sugar regulation – maintaining stable glucose levels during stress or fasting Energy production – mobilising fuel sources for physical and mental activity Immune system modulation – keeping immune responses balanced Inflammatory control – reducing excessive or chronic inflammation Sleep–wake cycle regulation – supporting circadian rhythm and sleep quality When cortisol levels become consistently too high (often in the early stages of stress) or too low (in later stages of burnout), it can disrupt these vital functions