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Similar to ARINA-1, the effect of bicarbonate with glutathione on MCT rates was independent of changes in ASL depth or CBF relative to PBS ( P = NS) (Figures 6C and 6D)
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Additionally, the high micromolar or millimolar concentrations are several fold above the reported affinity of these compounds to monoamine transporters or receptors (that can be found in the nM or low µM range) (Baumann et al., 2014, Simmler et al., 2014, Pitts et al., 2017, Zsilla et al., 2018, Luethi et al., 2019)