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Studies have shown that asymptomatic individuals with hyperuricemic already exhibit subclinical inflammation (e.g., elevated IL-6 and CRP), whereas acute gout flares are characterized by significant increases in IL-1β and S100A8/A9 levels, which may serve as distinguishing biomarkers (Ohashi et al., 2024
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[DOI] [PubMed] [Google Scholar] 137.Schwartzkroin P.A., Wyler A.R
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