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ROS disrupts the production of glycosaminoglycans and type II collagen fibers while increasing the expression of collagen type I, matrix metalloproteinases, and pro-inflammatory cytokines via the MAPK and MAPK/ERK signaling pathways (110)
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For example, in the context of induced pluripotent stem cells which are a promising player in the cell therapy field, GFs constitute the majority of essential components promoting cell growth, with 4 out of 6 components of the “essential medium” E8 being GFs (Chen et al., 2011)
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